教师简介
 
张金三(美籍)白求恩医科大学, 博士,教授,硕士生导师现任美国梅奥舒尔茨肿瘤新技术治疗中心主任研究员;温州大学生命科学与环境学院、温州医科大学药学院特聘专家,温州医科大学附属第一医院精准医疗中心技术主任。      

在美国排名第一的梅奥医学中心工作20 余年,主持多项美国国家级项目,回国后参与或主持国家基金2项,并与国际多位顶级科学家建立的合作关系。权威SCI论文60余篇,累计影响因子超过300、被引用1700余次。近期参加或主持多项国际高端会议并进行大会报告,兼任10余主流杂志的编委和审稿人。 

 

主要研究方向

FGF与肾损伤修复

HIPPO 信号通路的研究

肿瘤与干细胞的相关研究

 

主要社会兼职

 杂志编委:

Journal of Stem Cell & Regenerative Biology

杂志审稿:

Cell Death and Differentiation

Cell Death and Disease

Journal of Cell Sciences

Clinical Cancer Research

Seminars in Cancer Biology

Cancer Letters

Molecular Biology Journal

International Journal of Nanomedicine

Biomedical Research International

BMC Cancer

Surgical Oncology

  Oncotarget

Pancreatology

 

近三年发表文章

1. Claudia Chini, Jair Espindola-Netto, Gourish Mondal, Anatilde Gonzalez Guerrico, Veronica Nin, Carlos Escande, Mauro Sola-penna, Jin-San Zhang, Daniel Billadeau, and Eduardo chini. Clinical Cancer Research 2016 (in press)  (IF 8.738

2. Baumgart A, Chen NM, Zhang JS, Billadeau DD, Singh S, Fink D, Ströbel P, Klindt C, Hessmann E, Gress T, Ellenrieder V, Neesse S. GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression. Molecular Cancer Therapeutics 2015  (in press) (IF 5.579)

3. Hessmann E, Zhang JS, Chen NM, Hasselluhn M, Liou GY, Storz P, Ellenrieder V, Billadeau DD and Koenig A. NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation. Stem Cell International Volume 2015, Article ID 5272498.  http://dx.doi.org/10.1155/2016/5272498.  (IF 3.687)

4. Osborne DG, Piotrowski JT, Dick CJ, Zhang JS, Billadeau DD. SNX17 Affects T Cell Activation by Regulating TCR and Integrin Recycling. J Immunol. 2015 May 1;194(9):4555-66. PMID: 25825439  (IF 4.985)

5. Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E. NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas. Gastroenterology. 2015 May;148(5):1024-1034. PMID: 25623042  (IF 2.787)

6. Singh SK, Chen NM, Hessmann E, Siveke J, Lahmann M, Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Stiewe T, Gaedcke J, Mernberger M, Crawford HC, Bamlet WR, Zhang JS, Li XK, Smyrk TC, Billadeau DD, Hebrok M, Neesse A, Koenig A, Ellenrieder V. Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity. EMBO J. 2015 Feb 12;34(4):517-30. PMID: 25586376 (IF 9.643)

7. Deng ZH, Gomez TS, Osborne DG, Phillips-Krawczak CA, Zhang JS*, Billadeau DD*. Nuclear localized FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells. J Cell Sci. 2015 Jan 15; 128(2):373-84. PMID: 25431135.  (IF 4.706)

8. Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, van de Sluis B, Billadeau DD, Burstein E. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2014 Oct 29. pii: mbc.E14-06-1073. [Epub ahead of print] PMID: 25355947  (IF 4.037)

9. Meng XW, Koh BD, Zhang JS, Flatten KS, Schneider PA, Billadeau DD, Hess AD, Smith BD, Karp JE, Kaufmann SH. Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression. J Biol Chem. 2014 Jul 25;289(30):20543-58. PMID: 24895135  (IF 4.258)

10. Baumgart S, Chen NM, J. S, König A, Zhang JS, Singh SK, et al. Pro-inflammatory NFATc1 and STAT3 Transcription Pathway Promotes Pancreatitis-Associated Cancer initiation by KrasG12D. Cancer Discovery. 2014. (IF 19.783)

11. *Zhang JS, Herreros-Vilanueva M, Koenig A, Deng ZH, Artal-Martinez de Narvajas A, Meng X, Bujanda L, Ellenrieder V, Li XK, Kaufmann SH, Billadeau DD. Differential activity of GSK-3 isoforms toward NF-κB and TRAIL/TNFα- induced apoptosis in pancreatic cancer cells. Cell Death and Disease.  doi: 10.1038/cddis.2014.102. (IF 5.378)

12. Herreros-Villanueva M, Bujanda L, *Zhang JS. Embryonic Stem Factors and Pancreatic Cancer. World J of Gastroenterology. 20(9): 2247-2254. 2014. (IF 2.787)

 

科研课题

[1] GSK-3b调控NF-kB的分子机制及其在胰腺炎和胰腺癌变进程中的作用,国自然面81472601主持,经费64万2015.01-2018.12
[2] FGF7通过动员内源性干细胞促进肾损伤修复的机制,国自然青年(81500519)主要参与,经费21.6万,2016.01-2018.12 

 

指导研究生

郑晓梦    2014     温州医科大学药学院,信号转导与表观遗传

余丽霞    2014     温州医科大学药学院,信号转导与表观遗传

董晶莱    2015     温州医科大学药学院,信号转导与表观遗传

陈千杰    2015     温州医科大学药学院,信号转导与表观遗传

朱红梅    2015     温州医科大学药学院,信号转导与表观遗传