教师简介
 

姜潮 教授,博士生导师,中组部“千人计划”国家特聘专家,浙江省特聘专家,温州市第九届“雁荡友谊奖特别奖”获得者,所领导的团队获2012年温州市重点科技创新团队的称号。1994年获加拿大阿尔伯塔大学植物分子生物学博士学位。姜潮教授长期从事蛋白药物的研发,在多种生物反应器表达体系方面具有丰富的经验。曾在加拿大国家农业部和加拿大国家科学院从事研究工作,并先后在两家生物公司SemBioSys GeneticsPaladin Biosciences担任主任研究员和高级研究员,参与并领导了利用红花表达人胰岛素和载质蛋白-A1,昆虫细胞表达乙肝和丙肝疫苗等十余种蛋白类药物的研究和产业化。姜教授在国外权威期刊和国际会议上发表论文60余 篇, 其相关研究成果已获美国和中国专利。2010年回国后,发表论文十多篇,发明专利13项,指导带领的科研小组多次获得国家和省级基金项目,指导的研究生,博士生发表多篇SCI研究论文,且均顺利毕业并找到理想工作,其中三名硕士生荣获优秀研究生国家奖学金,两名硕士研究生分别顺利考取浙江大学和中国药科大学博士研究生。姜教授所领导的团队,逐步建立起药用蛋白及工,农业用蛋白的多种表达体系-植物悬浮细胞,昆虫细胞,植物油体和植物种子反应器;研究开发出的多种生物制品,一类新药及新型组织工程学复合生物材料已进入临床或已开展规范临床前试验研究阶段,已初步显示出广阔的应用前景和巨大的市场潜力。

研究方向:

 

生物反应器与药物研发、生物制药

 

学习经历:

 

博士 加拿大阿尔伯塔大学,植物分子生物学

硕士 吉林农业大学,农学

学士 东北农业大学,农学


工作经历:

1. 特聘教授,博导,(Distinguished Professor2016.04,至今,中国,温州大学生环学院;

2. 特聘教授,博导,(Distinguished Professor2010.08,至今,中国,温州医科大学药学院;

3. 客座教授(Guest Professor,2011.7至今,中国哈尔滨医科大学;

4. 特聘教授,博导,(Distinguished Professor2010.8-至今,中国,吉林农业大学,

教育部生物反应器与药物开发工程研究中心(Ministry  of  EducationEngineering

Research Center of  Bioreactor and Pharmaceutical Development);

5. 高级研究员 (Senior Research Scientist), 2009.02-2010.11, 加拿大, Paladin

Biosciences  公司(Paladin Biosciences, a Division of  Paladin Labs. Inc. Canada) ;

6. 项目主任高级研究员 (Team Leader and Senior Research Scientist), 1999.3-2009.1,  

加拿大,SemBioSys Genetics  公司(SemBioSys Genetics Inc, Calgary , Canada)

7. 助理研究员(Senior Research Associate),1996.6-1999.3,加拿大,国

家科学院植物生物技术研究所(Plant  Biotechnology  Institute, National Research

Council of  Canada, Saskatoon, Canada);

8. 博士后研究员(Post  Doctor fellow, 1994.1-1996.6,加拿大,加拿大

国家农业部植物研究中心(Eastern Cereal  and Oil-Seed Plant  Research Centre,

Agriculture Canada, Ottawa);

9. 讲师(Lecturer)1985.1-1988.12, 中国, 东北农业大学 (Northeast  Agriculture

University)。

 

部分研究论文:

 

1. Feng Zhai, Na Song, Haijun Wang, Haishan Tian, Weiyue Gong, Jisheng Ma, Xiaokun Li, Chao Jiang*. FGF18 promotes MC3T3-E1 cells proliferation and differentiation via ERK signaling pathway. Molecular Medicine Report, Accepted, 2016 

2. Meiyu Wu, Haijun Wang, Na Song, Jisheng Ma, Jiliang Cheng, Yang Zhao, Xiaokun Li, Chao Jiang*. High-level production of human FGF17 in Escherichia coli and the proliferation activity in NIH3T3 cells. Molecular Medicine Report, Accepted, 2016

3. Min Liu, Shenghui Chu, Jun Ai, Haiyan Li, Zhiyu Chen, Sisi Huang, Chao Jiang*, Xiaokun Li*. Application of oleosin-flanked keratinocyte growth factor-2 expressed from Arabidopsis thaliana promotes

hair follicle growth in mice. Plant Cell Technology, Accepted, 2016

4. Nuo Xu1,2, Yunpeng Wang2,4, Jisheng Ma3, Libo Jin2, Chao Jiang2*, Xiaokun Li1,2* A study on the immunogenicity of plant-derived fHbp-based meningococcal serogroup B subunit vaccine. Biotechnology Journal, Accepted, 2016IF=3.49

5. Li, Yong, Changye Sun, Ed yates, Jiang, Chao, Mark Wilkinson, Fernig, David. Heparin binding preference and structure in the fibroblast growth factor family parallel their evolutionary diversification. Open Biology, Accepted, 2016IF=5.78

6. Pongpun TanajakPiangkwan Sa-nguanmooXiaojie Wang ,Guang LiangXiaokun LiChao Jiang ,Siriporn ChattipakornNipon Chattipakorn. FGF21 therapy attenuates left ventricular dysfunction and metabolic disturbance by improving FGF21 sensitivity, cardiac mitochondrial redox homeostasis and structural changes in pre-diabetic ratsActa Physiologica · April 2016

7. Narattaphol CharoenphandhuPanan SuntornsaratoonNateetip KrishnamraPiangkwan Sa-nguanmoo ,Pongpun TanajakXiaojie Wang ,Guang LiangXiaokun LiChao Jiang ,Nipon Chattipakorn ,Siriporn Chattipakorn. Fibroblast growth factor-21 restores insulin sensitivity but induces aberrant bone microstructure in obese insulin-resistant rats Journal of Bone and Mineral MetabolismMar 2016 ·

8. Haishan Tian,Yang Zhao,Nazi Chen,Meiyu Wu,Weiyue Gong,Jie Zheng,David G Fernig,Alois Jungbauer,Dezhong Wang,Xiaokun Li*,Chao Jiang*.High production in E. coli of biologically active recombinant human fibroblast growth factor 20 and its neuroprotective effects, Applied Microbiology and Biotechnology, April 2016, Volume 100, Issue 7, pp 3023-3034IF=3.337

9. Nazi Chen1 , Jishen Ma1 ,Yang Zhao1 , Meiyu Wu1 , Huanhuan Yang1 ,Weiyue Gong1 ,Jiang Chao* , Xiaokun Li*Expression of functional recombinant human fibroblast growth factor 8b and its protective effects on MPP+-lesioned PC12 cells, Applied Microbiology and Biotechnology. January 2016, Volume 100, Issue 2, pp 625-635IF=3.337

10. Yi S, Yang J, Huang J, Guan L, Du L, Guo Y, Zhai F, Wang Y, Lu Z, Wang L, Li H, Li X*, Jiang C*.Expression of bioactive recombinant human fibroblast growth factor 9 in oil bodies of Arabidopsis thaliana[J]. Protein Expr Purif. 2015 Aug 11. PMID: 26276471(IF=1.695)

11. Huang J, Yang J, Guan L, Yi S, Du L, Tian H, Guo Y, Zhai F, Lu Z, Li H, Li X, Jiang C*.Expression of bioactive recombinant human fibroblast growth factor 10 in Carthamus tinctorius L. Seeds[J].Protein Expr Purif. 2015 Sep 15. PMID: 26384708(IF=1.695)

12. Dezhong Wang1,2,3,Jisheng Ma3,Difei Sun3,Haiyan Li2,Chao Jiang2,3*,Xiaokun Li12,3*Expression of bioactive anti-CD20 antibody fragments and induction of ER stress response in Arabidopsis seeds. Applied Microbiology and Biotechnology. 09 May,2015.IF= 3.3

13. Hongrui Li1• Jing Yang1 • Yubin Chen1 • Dezhong Wang1 • Lili Guan1 • LinNa Du1 • YongXin Guo1 • Haiyan Li1 • Chao Jiang1* • Xiaokun Li1*. Expression of a functional recombinant oleosin-human hyaluronidase hPH-20 fusion in Arabidopsis thaliana. Protein Expression and Purfication ,2014,103,23-27(IF=1.695)

14. Ping Xue, Xiaojing Zhu, Junqing Shi, Min Liu,Jian Zhang, Chao Jiang*,Xiaokun Li*.Highly efficient expression of functional recombinant human keratinocyte growth factor 1 and its protective effects on hepatocytes. Applied Microbiology and Biotechnology. 2014,98(9),3933-45.IF=3.337

15. Lintao SongZhifeng Huang, Yu ChenHaiyan LiChao Jiang* Xiaokun Li*. High efficiency production of bioactive recombinant human fibroblast growth factor 18 in Escherichia coli and its effects on hair follicles growth. Applied Microbiology and Biotechnology,2014,98(2):695-704. (IF=3.337

16. Xiaoju Liu, Yubin Chen, Xiaoping Wu, Haiyan Li, Chao Jiang, Haishan Tian, Lu Tang, Dezhong Wang, Ting Yu and Xiaokun Li.SUMO fusion system facilitates soluble expression and high production of bioactive human fibroblast growth factor 23 (FGF23) .Applied Microbiology and Biotechnology ,2012,96(1):103-111

17. Qi Q., Rajala R.V., Anderson W., Jiang C., Rozwadowski  K., Selvaraj  G.,Sharma R., Datl a R (2000). Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA: protein N-myristoyl transferase from Arabidopsis thaliana. J biol chem, 275: 9673-9683.

18. Jiang, C., Iu, B. and Singh, J (1996). Requirement of a CCGAC cis-acting element for cold- induction of the BN115 gene of winter Brassica napus. Plant Molecular Biology 30, 679-684.

19. Jiang, C., Escher, A. and Szalay, A.A (1993). Alteration of a luciferase based binary plant transformation vector f or simultaneous expression of desired gene products and bacterial luciferase in transgenic plants. Bioluminescence and chemiluminescence, Status Report. Szal ay, A.A., Kricka, L. and Stanley, P. (Eds) John Wiley & Sons, 127-131.

20. Jiang, C., Langr i dge, W.H.R. and Szalay , A.A (1993). Isolation of devel opmentallyregulated promoter elements from tobacco by T-DNA insertional activation of promoterless luciferase marker gene. Bioluminescence and chemiluminescence, Status Report. Szalay, A.A., Kr i cka, L. and Stanley, P. (Eds) John Wiley & Sons, 217-221.

21. Langridge, W.H.R., Jiang, C., Wang, G., Giacomin, L., Dale, P., Baga, M., Fodor, I. and Szal ay, A.A (1993). Use of a luciferase marker gene system to monitor gene expression in bacteria, plants and virus infected animal cells. Bioluminescence and chemiluminescence, Status Report. Szalay , A.A., Kr icka, L. and Stanl ey, P.  (Eds) John Wiley & Sons222-226 .

22. Jiang, C., Langr idge, W.H.R. and Szalay, A. A (1992). Identification of plant genes in vivo by tagging with T-DNA border-linked luciferase gene followed by inverse polymerase chain reaction amplification. Plant Molecular Biology Reporter 10, 345-61.

 

主持或参加的主要科研项目:

1. 红花油体生物反应器研制与产品开发(SQ2010AA1000691008),“863”项目,855

2. 油体蛋白-成纤维细胞生长因子10融合蛋白外用制剂开发(13C26212201223),国家中小企业创新基金,2013-2015年,70

3. 温州市重点科技创新团队 (2010R50042),33

4. 重组人酸性成纤维细胞生长因子改构体治疗糖尿病足新药临床前研究(2013ZX09103003005),国家重大科技专项,2013年,129.74

5. bFGF对氧化应激相关酶的调控及其在促糖尿病皮肤创面修复中的作用(81170750),国家自然科学基金,2012-2015年,58

6. Dami 细胞向巨核细胞的定向分化、成熟及其信号机理研究(LY13H080004),浙江省自然科学基金,2013-2015年,8

7. 利用红花油体表达系统对新型oleosin-FGF10融合蛋白载体构建策略的研究(LY13H300006),浙江省自然科学基金,2013-2015年,8

科研奖励:

2010以“红花油体等生物反应器关键技术研究与应用”荣获吉林省科学技术奖,技术发明一等奖

授权专利:

1. COLD INDUCED PROMOTER FROM WINTER BRASSICA NAPUS, Date of Patent :Dec.8,1998,Patent Number:US005847102A

2. 成纤维细胞生长因子-1改构体凝胶剂制备及其在糖尿病足治疗中的应用,2012年,专利号:201210430489.7

3. 一种降血糖的药物组合,2014年,专利号:ZL 2012 1 0146676.2

4. 一种防治前列腺疾病的药物组合物,2014年,专利号:ZL 2012 1 0055473.2

5. 含有KGF2的植物油体凝胶剂凝胶,2015年,专利号:ZL 2013 1 0333810.4

6. 一种含有角质细胞生长因子KGF2的植物油体,ZL 201310333809.1

国际会议报告,墙报:

 

Jiang, C. Oral presentationTranslational Medicine: Development of Fibroblast Growth Factors as Pharmaceuticals in ChinaGordon Research Conference Fibroblast Growth Factors in Development and Diseases, 04-09 June 2016, Hong Kong, China

Jiang, C. Oral presentationDevelopment of Oliosen-FGF Fusions for Topical ApplicationsFibroblast Growth Factors in Development and Repair Conference, 04-07 February 2015, Cancun, Mexico

姜潮,2015年中国生物工程学会年会并作大会报告。生物反应器与医药工业,2015116-8日(中国上海)

姜潮,2015年中日韩药学论坛,日本北陆大学,2015819-21日(日本金泽)

姜潮,2014年中国生物工程学会年会并作大会报告。植物生物反应器在工业,农业和医药上的应用(中国温州)

姜潮,参加2014年关于生长因子与疾病的高登国际会议并参加大会墙报交流201421-8日(美国洛杉矶)

姜潮,参加2012年关于生长因子与疾病的高登国际会议并参加大会墙报交流2012511-17日(瑞士洛桑);

姜潮,协办“植物反应器武汉高峰论坛”2012925-26日(中国武汉);

姜潮,协办“2012第三届国际FGF大会”(温州)外国专家接待,大会主持兼翻译,大会发言。

10 姜潮,参加2011年中日前沿生物技术论坛并在大会发表演讲(日本东京);

11 姜潮,参加2011年中国生长因子暨肝细胞高峰论谈并在大会发表演讲(中国温州)

12 Jiang,C., Huel, R., van Rooijen, G. and Moloney , M (2003). Effect of  promotertiming on differential protein accumulation and sub-cellular targeting in seeds.Conference Proceedings, ISPMB 7th International Congress of Plant Molecular Biology .

13 Jiang,C., Seon, J., Keon, R., Moloney , M and van Rooijen, G (2000). Optimization of oleosin and oleosin fusion in transgenic oilseeds. Conference Proceedings, American Society of Plant Biologist.  

14 Jiang, C., Dat l a, R., G., Sudam, P., Keller, W and Selvaraj , G (1999). Isolation and characterization of a tobacco cysteine proteinase promoter: Circadian, light and hormonal regulation. Conference Proceedings, Kaystone Symposiumon Molecular and Cellular Biology.

15 Jiang, C., Dat a, R., G., Keller, W and Selvaraj , G (1997). Isolation and characterization of two organ-specific promoters from tobacco tagging lines. Poster Presentation, Golden Research Conference in Gene Silencing.

16 Jiang, C., Iu, B. and Singh, J (1996). Introduction of dehydration and salt response in a cold- induced promoter by base-substitutions of a low temperature responsive cis-acting element.Conference Proceedings,the First Molecular Farming Conference.

17 Jiang, C, Iu, B. and Singh, J (1995). Functional analyses, by base-substitution, of cis-acting elements required for expression of a cold- induced gene BN115 from winter Brassica napus. Conference Proceedings, Golden Research Conference in Temperature Stress.

18 Jiang, C., Iu, B., Whi te, T. and Singh, J. (1994) Mutation analyses of two low-temperature-response-elements (LTREs) in the BN115 promoter from winter Brassicanapus. Conference Proceedings, Canadian Society of Plant Physiologists.

19 Langridge, W.H.R., Jiang, C., Wang, G., Giacomin, L., Dale, P., Baga, M., Fodor, I. and Szal ay, A.A  (1993). Use of a luciferase marker gene system to monitor gene expression in bacteria, plants and virus infected animal cells. Bioluminescence and Chemiluminescence Conference Banff, AB Canada.