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教师简介
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个人简介

  佟海滨,现就职于温州大学生命与环境科学学院,东北师范大学细胞生物学专业博士,中国中医科学院博士后,美国耶鲁大学访问学者,副研究员,硕士研究生导师。主要从事天然多糖化合物的活性研究。主持国家自然科学基金面上项目、青年项目,中国博士后科学基金面上资助,吉林省科技厅重点科技攻关项目、优秀青年基金,浙江省自然科学基金面上项目等。近年来以第一作者及通讯作者身份发表SCI收录论文二十余篇,授权国家发明专利3项,获得省部级以上科研奖励6项,荣获首批“吉林省高校科研春苗人才”以及“吉林市青年科技创新创业人才”称号。2016年获得“吉林省青年科技奖”。


承担科研项目:

1. 柴胡中基于P-selectin靶点治疗急性肺损伤的新型糖类先导化合物的发现与作用机制研究(项目编号:81872952),国家自然科学基金面上项目,项目负责人。

2. 羊栖菜多糖功能性糖链基序基于P-selectin靶点发挥急性肺损伤保护作用的机制研究(项目编号:LY18C020006),浙江省自然科学基金面上项目,项目负责人。

3. 柴胡多糖拮抗P-选择素发挥急性肺损伤保护作用的研究(项目编号:2017M610155),中国博士后科学基金第61批面上资助一等,项目负责人。

4.  c-Abl激酶在中性粒细胞应答剪切力爬行进程中的分子行为及作用机制研究(项目编号:31401203),  国家自然科学基金青年项目,项目负责人。

5. 基于P-selectin功能拮抗的柴胡多糖核心糖链基序的纯化及新型糖类抗炎药物开发(项目编号:20140204039YY),吉林省科技厅重点科技攻关项目,项目负责人。

6. 基于p-selectin靶点的柴胡多糖拮抗剂筛选及抗炎构效关系研究(项目编号:201201143),吉林省科技厅优秀青年基金,项目负责人。

 

近五年代表性论文

1.Tong, H.B., Wu, S.Y., Song K.X., Liu J., Song X.D., Zhang X., Huang L.Q.*, Wu, M.J.* Characterization of a P-selectin-binding moiety from Bupleurum chinense polysaccharide and its antagonistic effect against P-selectin-mediated function. Carbohydrate Polymers, 2018, 196: 110-116.SCIIF5.1582Top

2. Tong, H.B., Zheng, X.L., Song, J.X., Liu, J., Ren, T., Zhang, X., Huang, L.Q.*, Wu, M.J.* Radical scavenging activity of sulfated Bupleurum chinense polysaccharides and their effects against oxidative stress-induced senescence. Carbohydrate Polymers, 2018, 192: 143-149. SCIIF5.1582Top

3. Tong, H.B., Qi, D.K., Guan, X.G., Jiang, G.Q., Liao, Z.Y., Zhang, X., Chen, P.C., Li, N., Wu, M.J.* c-Abl tyrosine kinase regulates neutrophil crawling behavior under fluid shear stress via Rac/PAK/LIMK/cofilin signaling axis. Journal of Cellular Biochemistry, 2018, 119:2806–2817. SCIIF2.9593区)

4. Song, X.F., Ren, T., Zheng, Z., Lu, T.C., Wang, Z.C., Du, F.G., Tong, H.B.* Anti-tumor and immunomodulatory activities induced by an alkali-extracted polysaccharide BCAP-1 from Bupleurum chinense via NF-κB signaling pathway. International Journal of Biological Macromolecules, 2017, 95: 357-362. SCIIF3.9092区,通讯作者

5. Tong, H.B., Jiang, G.Q., Qi, D.K., Bi, J.F., Tian, D., Guan, X.G., Zheng, S., Sun, X.* Bupleurum chinense polysaccharide inhibit adhesion of human melanoma cells via blocking β1 integrin function. Carbohydrate Polymers, 2017, 156: 244-252. SCIIF5.1582Top

6. Tong, H.B., Jiang, G.Q. Guan, X.G., Wu, H., Song, K.X., Cheng, K., Sun, X.* Characterization of a polysaccharide from Rosa davurica and inhibitory activity against neutrophil migration. International Journal of Biological Macromolecules, 2016, 89: 111-117. SCIIF3.9092区)

7. Chen, Y.F., Lee, H.J., Tong, H.B., Schwartz, M., Zhu, C.* Force regulated conformational change of integrin αVβ3. Matrix Biology, 2017, 60: 70-85. SCIIF4.4702区)

8. Baeyens, N., Larrivée, B., Ola, R., Hayward-Piatkowskyi, B., Dubrac, A., Huang, B., Ross, T.D., Coon, B.G., Min, E., Tsarfati, M., Tong, H.B., Eichmann, A., Schwartz, M.A.* Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia (HHT). Journal of Cell Biology, 2016, 214(7):807-816. SCIIF8.7171区)

9. Li, S., Sheng, L.X., Xu, J.B., Tong, H.B., Jiang, H.B.* The induction of metallothioneins during pulsed cadmium exposure to Daphnia magna: Recovery and trans-generational effect. Ecotoxicology and Environmental Safety, 2016, 126:71-77. SCIIF3.1303区)

10. Tong, H.B., Mao, D.R., Zhai, M.Y., Zhang, Z.R., Sun, G.R., Jiang, G.Q.* Macrophage activation induced by the polysaccharides isolated from the roots of Sanguisorba officinalis. Pharmaceutical Biology, 2015, 53: 1511-1515. SCIIF1.9164区)

11. Tong, H.B., Song, J.X., Zhang, Z.R., Mao, D.R., Sun, G.R., Jiang, G.Q. Inhibitory function of P-selectin-mediated leukocyte adhesion by the polysaccharides from Sanguisorba officinalis. Pharmaceutical Biology, 2015, 53: 345-349. SCIIF1.9164区)

12. Tong, H.B., Tian, D., Li, T.B., Wang, B., Jiang, G.Q. Sun, X. Inhibition of inflammatory injure by polysaccharides from Bupleurum chinense through antagonizing P-selectin. Carbohydrate Polymers, 2014, 105:20-25. SCIIF4.8112区)

13. Kong, F.L., Li, F.E., He, Z.M.,, Jiang, Y., Hao, R.Y., Sun, X., Tong, H.B.* Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from Pleurotus ostreatus. International Journal of Biological Macromolecules, 2014, 69:561–566. SCIIF3.9092区,通讯作者

14. Tong, H.B., Zhao, B., Shi, H.F., Ba, X.Q., Wang, X.G., Jiang, Y., Zeng, X.L. c-Abl tyrosine kinase plays a critical role in β2 integrin-dependent neutrophil migration by regulating Vav1 activity. Journal of Leukocyte Biology, 2013, 93:611-622. SCIIF4.1652区)

15. Tong, H.B., Tian, D., He, Z.M., Liu, Y., Chu, X.D., Sun, X. Polysaccharides from Bupleurum chinense impact the recruitment and migration of neutrophils by blocking fMLP chemoattractant receptor-mediated functions. Carbohydrate Polymers, 2013, 92 :1071-1077. SCIIF5.1582区)

16. Tong, H.B., Liu, X.M., Tian, D., Sun, X. Purification, chemical characterization and radical scavenging activities of alkali-extracted polysaccharide fractions isolated from the fruit bodies of Tricholoma matsutake. World Journal of Microbiology & Biotechnology, 2013, 29:775-780. SCIIF1.5323区)

 

发明专利

1. 一种北柴胡多糖片段的纯化工艺及其在制备抗炎药物中的应用ZL 201610151866.1

2. 山竹果皮花色苷的提取方法及其在制备抗炎药物中的应用ZL 2010 1 0132394.8

3. 一种高纯度松茸多糖提取工艺ZL 2011 1 0072492.1

 

获奖情况

1. 吉林省青年科技奖 2016

2. 吉林省自然科学奖,二等奖,2015 (第二完成人)

3. 吉林省科技进步奖,二等奖,2013 (第二完成人)

 

联系电话

13819706331676331

 

电子邮箱

tonghaibin@gmail.com

tonghb@wzu.edu.cn