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高艺恬简历

个人

简介

高艺恬,女,1989年9月,博士,青年硕士生导师,温州市海外精英引进计划-创新长期项目人才

学习

经历

2014.09–2017.07:博士(药物生物技术),英国贝尔法斯特女王大学,药学院

(获优秀博士奖学金)

2011.09–2014.06:硕士(药物分析),沈阳药科大学,药学院

2007.09–2011.07:学士(药学),沈阳药科大学,药学院

研究

方向

天然及基于靶点设计的活性多肽的抗菌及抗炎活性和机制研究

1.天然抗菌肽的发现及改造

2.肽类药物的研究与开发

主持

项目

1. 靶向优化的新型抗菌肽MS-PT1a抗耐甲氧西林金黄色葡萄球菌的作用机制研究,国家自然科学基金青年项目(81803590),经费21万,2019.01.01-2021.12.31

2. 特异性抗MRSA抗菌肽的设计优化及其抗菌机制研究,温州市基础性医疗卫生科技项目(Y20180178),经费2万元,2019.01.01-2021.12.31。

主要

论文

1. Wu, D#., Gao, T#., Tan, Y., Liu, Y., Wang, L., Zhou. M., Xi. X., Ma, C., Olaf, R.P., Chen, T., Chaw, C.., (2018) Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. Frontiers in Microbiology, 9:541. ((equal contribution, IF=4.076)

2.Gao, Y., Wu, D., Wang, L., Chen, L., Ma, C., Xi, X., Zhou, M., Duan, J., Olaf, R, P., Chen, T. and Shaw, C., (2017) Targeted modification of a novel amphibian antimicrobial peptide from Phyllomedusa tarsius to enhance its activity against MRSA and microbial biofilm. Frontiers in microbiology 8: 628 (IF=4.076).

3.Gao, Y., Wu, D., Xi, X., Wu, Y., Ma, C., Zhou, M., Wang, L., Yang, M., Chen, T. and Shaw, C., (2016) Identification and characterisation of the antimicrobial peptide, Phylloseptin-PT, from the skin secretion of Phyllomedusa tarsius, and comparison of activity with designed, cationicityenhanced analogues and diastereomers. Molecules, 21: 1667 (IF=2.861).

4. Wu, D#.,Gao, Y#., Wang, L., Xi, X., Wu, Y., Zhou, M., Zhang, Y., Ma, C., Chen, T. and Shaw, C.,(2016), A combined molecular cloning and mass spectrometric method to identify, characterize, and design Frenatin peptides from the skin secretion of Litoria infrafrenata. Molecules, 21:1429. (equal contribution, IF=2.861).

5. Shi, D., Hou, X., Wang, L.,Gao, Y., Wu, D., Xi, X., Zhou, M., Kwok, H., Duan, J., Chen, T. et al.,(2016), Two novel Dermaseptin-like antimicrobial peptides with anticancer activities from the skin secretion of Pachymedusa dacnicolor.Toxins.8: 144 (IF=3.030).

6. Shi, D., Xi, X., Wang, L.,Gao, Y., Ma, C., Chen, H., Zhou, M., Chen, T. and Shaw, C., (2016), Baltikinin: A new yyotropic tryptophyllin-3 peptide Isolated from the skin secretion of the purple-sided leaf frog, Phyllomedusa baltea.Toxins.8: 213 (IF=3.030).

7. Yang, N., Li, L., Wu, D.,Gao, Y., Xi, X., Zhou, M., Wang, L., Chen, T. and Shaw, C., (2016) Discovery of novel bacterial cell-penetrating Phylloseptins in defensive skin secretions of the south American Hylid frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. Toxins. 8: 255 (IF=3.030).

8.Gao, Y.,Zhao, L., Sheng, M., Wang, M., Zhao, C., (2014) Determination of the contents of four7 fatty acids in soybean oil for injection by GC-MS and GC. Journal of Shenyang Pharmaceutical University, 30 (9): 704-708.

9.Gao, Y., Zhao, L., Sheng, M., Wang, M., Zhao, C., (2014) Studying on the compatibility of soybean oil for injection and high density polyethylene bottles.West China Journal of Pharmaceutical Sciences. 29 (2): 164-166.


承担

课程

药物分析、细胞生物学(中/英文)、仪器分析(中/英文)


联系

方式

Tel:13625771761;Email:gaoyitianwzu@outlook.com