金宁一

金宁一研究员是我国病毒学和人兽共患病学的学科带头人，长期坚持在科研和防控工作第一线，围绕病原、流行病学、诊断和疫苗等病毒病防控理论和关键技术进行科学研究。自1982年以来，曾主持国家及省部级课题57项；获省部级科技二等奖以上17项，其中作为第一完成人获国家科技进步一等奖1项、省部级科技进步一等奖4项、二等奖5项，授权国家发明专利12项，成果转让2项，获新型疫苗转基因生物安全证书6项，以责任作者在Nature Communication、Science Signaling和Cell Research等国内外期刊发表研究论文429篇，主编专著2部。2014年获“何梁何利”科技进步奖，兽医界第一个国家杰出青年基金（1998）获得者，2000年享受政府特殊津贴，2005年被评为全国优秀科技工作者，获军队杰出专业技术人才奖、全军优秀教员、感动中国畜牧兽医科技创新领军人物、新中国60年畜牧兽医科技贡献奖（杰出人物）等荣誉。

主要研究方向

作为我国病毒性传染病学和人兽共患病学学科带头人，长期从事病原发现、流行病学、生态背景、病毒基因组功能、病毒载体系统构建、常规疫苗与新型疫苗、快速侦检、人兽共患病综合防治和生物高技术相关产品研发等研究领域形成了明显的优势和特色，并取得了突出成就。

主要社会兼职

2003.6-2008.12 国务院学位委员会第五届学科评议组 成员

2009.11-至今 全国动物防疫专家委员会 委员

2000.8-至今 中国人民解放军医学科学技术委员会 委员

2001.12-至今 中国畜牧兽医学会 常务理事

2005.9-至今 中国畜牧兽医学会动物传染病学分会 理事长

2006.10-2011.10 中国微生物学会病毒学专业委员会 副主任委员

代表性成果

[1]YAN YI-WU, Zou Zhen, SUN YANG, LI XIAO, SU KAI-FENG, WEI YU-QUAN, JIN NING-YI, JIANG CHENG-YU. Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model. Cell research. 2013, 23(2): 300-302.

[2]Zou Zhen, Yan Yi-wu, Shu YUE-LONG, Gao RONG-BAO, Sun Yang, Li Xiao, Ju XIANG-WU, Liang ZHU, Liu Qiang, Zhao YAN, Guo FENG, Bai Tian, Han Zong-sheng, Zhu Jin-dong, Zhou Huan-di, Huang Feng-ming, Li Chang, Lu Hui-jun, Li Ning, Li Dang-sheng, JIN NING-YI, Penninger Josef-M, JIANG CHENG-YU. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nature communications. 2014, 5:3594.

[3]SUN YANG, LI CHENG-GANG, SHU YUE-LONG, JU XIANG-WU, ZOU ZHEN, WANG HONG-LIANG, RAO SHUAN, GUO FENG, LIU HAO-LIN, NAN WEN-LONG, ZHAO YAN, YAN YI-WU, TANG JUN, ZHAO CHEN, YANG PENG, LIU KANGTAI, WANG SHUNXIN, LU HUI-JUN, LI XIAO, TAN LEI, GAO RONG-BAO, SONG JING-DONG, GAO XIANG, TIAN XINLUN, QIN YING-ZHI, XU KAI-FENG, LI DANG-SHENG, JIN NING-YI, JIANG CHENG-YU. Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection[J]. Science signaling, 2012, 5 (212): ra16.

[4]LI XIAO, LIU YAN, WEN ZHONG-MEI, LI CHANG, LU HUI-JUN, TIAN MING-YAO, JIN KUO-SHI, SUN LI-LI, GAO PENG, YANG EN-CHENG, XU XIAO-HONG, KAN SHI-FU, WANG ZHUO-YUE, WANG YU-HANG, JIN NING-YI. Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo. Molecular cancer. 2010, 9: 10.

[5]LI XIAO, JIN NING-YI, MI ZHI-QIANG, LIAN HAI, SUN LI-LI, LI XUE-MEI, ZHENG HONG-LING. Antitumor effects of a recombinant fowlpox virus expressing Apoptin in vivo and in vitro. International journal of cancer. 2006, 119 (12): 2948-2957.

[6]LIAN HAI, JIN NING-YI, LI XIAO, MI ZHI-QIANG, ZHANG JING-MIN, SUN LI-LI, LI XUE-MEI, ZHENG HONG-LING, LI PING. Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and Apoptin. Cancer immunology immunotherapy. 2007, 56 (2): 181-192.

[7]QI YAN-XIN, GUO HUAN-HUAN, HU NING-NING, HE DONG-YUN, ZHANG SHI, CHU YUN-JIE, HUANG YU-BIN, LI XIAO, SUN LI-LI, JIN NING-YI. Preclinical pharmacology and toxicology study of Ad-hTERT-E1a-Apoptin, a novel dual cancer-specific oncolytic adenovirus. Toxicology and applied pharmacology. 2014 Oct 15;280(2):362-9.

[8]KAN SHI-FU, WANG YU-HANG, SUN LI-LI, JIA PENG, QI YAN-XIN, SU JIA-QIANG, LIU LEI, YANG GUO-HUA, LIU LI-MING, WANG ZHUO-YUE, WANG JIN-HUI, LIU GUANG-CHEN, JIN NING-YI, LI XIAO, DING ZHUANG. Attenuation of vaccinia Tian Tan strain by removal of viral TC7L-TK2L and TA35R genes. PloS one. 2012, 7 (2): e31979.

[9]MA MING-XIAO, JIN NING-YI, WANG ZHEN-GUO, WANG RUI-LIN, FEI DONG-LIANG, ZHENG MING, YIN GE-FEN, LI CHANG, JIA LIE-LI, JIN KUO-SHI, ZHANG YING-JIU. Construction and immunogenicity of recombinant fowlpox vaccines coexpressing HA of AIV H5N1 and chicken IL18. Vaccine. 2006, 24 (20): 4304-4311.

[10]SHEN GUO-SHUN, JIN NING-YI, MA MING-XIAO, JIN KUO-SHI, ZHENG MING, ZHUANG TIAN-ZHONG, LU HUI-JUN, ZHU GUANG-ZE, JIN HONG-TAO, JIN MING-LAN, HUO XIAO-WEI, QIN XIAO-BING, YIN RONG-LAN, LI CHANG, LI HONG-WEN, LI YANG, HAN ZHEN-ZHEN, CHEN YI-FENG, JIN MIAO-MIAO. Immune responses of pigs inoculated with a recombinant fowlpox virus coexpressing GP5/GP3 of porcine reproductive and respiratory syndrome virus and swine IL-18. Vaccine. 2007, 25 (21): 4193-4202.

科研课题

[1]科技部国际合作项目，流感跨种通用重组腺病毒疫苗关键制备技术合作研究，主持人

[2]973项目，人兽共患病生态学及免疫机制研究，主持人

[3]863项目，无细胞百白破-乙肝-流感嗜血杆菌等联合疫苗关键技术及产品研发 ，主持人

[4]科技部项目，重组疫苗通用载体构建与应用技术平台，主持人

[5]973项目，农业生物安全与关键技术研究，主持人