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教师简介
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个人简介
佟海滨,生于1981年6月,现就职于温州大学生命与环境科学学院,东北师范大学细胞生物学专业博士,中国中医科学院博士后,美国耶鲁大学访问学者,副教授,硕士研究生导师。主要从事针对黏附分子靶点具有细胞黏附拮抗作用的活性多糖组分的筛选及开发工作,以及由黏附分子介导的细胞黏附与迁移的分子调控与干预机制研究。近年来以第一作者及通讯作者身份发表SCI收录论文二十余篇,主持省部级以上项目8项,获得省部级以上科研奖励6项,申报及授权国家发明专利3项。荣获首批“吉林省高校科研春苗人才”以及“吉林市青年科技创新创业人才”称号。2016年获得“吉林省青年科技奖”。

代表性论文
1. Song, X.F., Ren, T., Zheng, Z., Lu, T.C., Wang, Z.C., Du, F.G., Tong, H.B.* Anti-tumor and immunomodulatory activities induced by an alkali-extracted polysaccharide BCAP-1 from Bupleurum chinense via NF-κB signaling pathway. International Journal of Biological Macromolecules, 2017, 95: 357-362. (IF:3.138,通讯作者)
2. Tong, H.B., Jiang, G.H., Qi, D.K., Bi, J.F., Tian, D., Guan, X.G., Zheng, S., Sun, X.* Bupleurum chinense polysaccharide inhibit adhesion of human melanoma cells via blocking β1 integrin function. Carbohydrate Polymers, 2017, 156: 244-252. (IF:4.219)
3. Tong, H.B., Zhao, B., Shi, H.F., Ba, X.Q., Wang, X.G., Jiang, Y., Zeng, X.L.* c-Abl tyrosine kinase plays a critical role in β2 integrin-dependent neutrophil migration by regulating Vav1 activity. Journal of Leukocyte Biology, 2013, 93:611-622. (IF:4.165,)
4. Tong, H.B., Song, X.F., Sun, X., Sun, G.R., Du, F.G.* Immunomodulatory and antitumor activities of grape seed proanthocyanidins. Journal of Agricultural and Food Chemistry, 2011, 59:11543-11547. (IF:2.857)
5. Tong, H.B., Xia, F.G., Feng, K., Sun, G.R., Gao, X.X., Sun, L.W., Tian, D. and Sun, X.* Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus. Bioresource Technology, 2009, 100:1682-1686. (IF:4.917)

研究方向和课题承担
主要研究方向:多糖化学与生物学;海藻及中药活性产物研究及开发。

主持科研项目:
1. 羊栖菜多糖功能性糖链基序基于P-selectin靶点发挥急性肺损伤保护作用的机制研究,浙江省自然科学基金一般项目,项目编号:LY18C020006,2018.01至2020.12,项目负责人。
2. c-Abl激酶在中性粒细胞应答剪切力爬行进程中的分子行为及作用机制研究,国家自然科学基金青年项目,项目编号:31401203,2015.01至2017.12,项目负责人。
3. 基于P-selectin功能拮抗的柴胡多糖核心糖链基序的纯化及新型糖类抗炎药物开发,吉林省科技厅重点科技攻关项目,项目编号:20140204039YY,2014.01至2016.12,项目负责人。
4. 基于p-selectin靶点的柴胡多糖拮抗剂筛选及抗炎构效关系研究,吉林省科技厅优秀青年基金,项目编号:201201143, 2012.01至2014.12,项目负责人。
5. 拮抗p-选择素靶点的多糖类抗炎化合物筛选及构效关系研究,吉林省教育厅“吉林省高校科研春苗人才”项目,项目编号:2012-171,2013.01至2014.12,项目负责人。
专著及获奖情况
1. 吉林省青年科技奖 2016年
2. 吉林省自然科学奖,二等奖,2015 (第二完成人)
3. 吉林省科技进步奖,二等奖,2013 (第二完成人)

联系电话:18604498917,13819706331(736331)
电子邮箱:tonghaibin@gmail.com

Selected Publications
1、Anti-tumor and immunomodulatory activities induced by an alkali-extracted polysaccharide BCAP-1 from Bupleurum chinense via NF-κB signaling pathway. International Journal of Biological Macromolecules, 2017, 95: 357-362. (IF:3.138,Corresponding author)
2、Bupleurum chinense polysaccharide inhibit adhesion of human melanoma cells via blocking β1 integrin function. Carbohydrate Polymers, 2017, 156: 244-252. (IF:4.219)
3、c-Abl tyrosine kinase plays a critical role in β2 integrin-dependent neutrophil migration by regulating Vav1 activity. Journal of Leukocyte Biology, 2013, 93:611-622. (IF:4.165,)
4、Immunomodulatory and antitumor activities of grape seed proanthocyanidins. Journal of Agricultural and Food Chemistry, 2011, 59:11543-11547. (IF:2.857)
5、Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus. Bioresource Technology, 2009, 100:1682-1686. (IF:4.917)
Selected Projects
1、Mechanism of functional sugar chain motifs of Sargassum fusiforme polysaccharide on the protection of acute lung injury based on P-selectin target, Zhejiang Provincial Natural Science Foundation (LY18C020006), 01/2018-12/2020
2、The molecular behavior and mechanism of c-Abl kinase in neutrophil crawling under shear stress, National Natural Science Foundation of China (31401203), 01/2015-12/2017
3、Purification of the core sugar chain motif of Bupleurum polysaccharides with antagonistic effect against P-selectin function and development of new carbohydrate anti-inflammatory drugs, Key scientific and technological project of Jilin Provincial Science and Technology Department (20140204039YY) 01/2014-12/2016
4、Antagonistic effect of polysaccharides with anti-inflammatory function against p-selectin targets and the study of structure-activity relationship, Jilin Provincial Department of Education, "Jilin Province, University of Science and Technology talent" project (2012-171), 01/2013-12/2014
Honors and Awards
1. Jilin Province Youth Science and Technology Award, 2016
2. Jilin Province Natural Science Award, second prize, 2015
3. Jilin Province Science and Technology Progress Award, second prize, 2013