Zhiyong Liao Ph.D
College for Life and Environmental Science
Cha-Shan University Town
Tel: 86-577-86597351; Fax: 86-577-86689257
Education and job experience
1994-1998: Department of Chemistry, Jiangxi Normal University, China. B.S
1998-2003: College of Life Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. Ph.D
2004-2005: College of Life Sciences, Jiangxi Normal University. Assistant professor
2005-2007: National Institute of Health, National Institute of Cancer, USA, Postdoctor
2008-2013: College of Life and Environmental Science, Wenzhou University, Associate professor
2014-present: College of Life and Environmental Science, Wenzhou University, Professor
 Isolation of bioactive compounds from medicinal plants and animals and pharmacological research, such as anti-diabetic, anti-tumor and anti-aging.
 Identification, cloning, expression, structure and function of metabolism- or immune response-related genes from medicinal plants and animals.
 Breeding and improvement of medicinal plants and animals.
 Character evaluation of tartary buckwheat germplasm resources in East China ecological region, active ingredient excavation, forage development and promotion. National Key R&D Program Intergovernmental International Science and Technology Innovation Cooperation Key Project (Grant No: YS2017YFGH001734), 2019.01-2022.12.
 Screening of the Sargassum fusiforme polysaccharide fractions with anti-aging effect and preliminary study on anti-aging mechanism. Funded by National Natural Science Foundation of China (Grant No: 31470430), 2015.01-2018.12.
 Excavation, transformation and anti-diabetic effects of flavonoids from Cirsium japonicum. (Grant No: 21276200), 2013.01-2016.12.
 The formation mechanism of antigen receptor diversity and its origin. Funded by the National Basic Research Program of China (Grant No: 2013CB835301), 2013.01-2017.08.
 Study on the excavation and antitumor activity of new birch alcohols. (Grant No: Z2100435), 2010.06-2013.06.
 Anti-tumor activity of novel Betulin compounds and the related functional mechanism. Funded by Natural Science Foundation of Zhejiang (Grant No: Y20110853), 2011.01-2012.12.
 Development of novel diagnostic kit of Hepatitis C virus. Funded by Zhejiang Science and Technology Program (Grant No: 2010C33173), 2011.01-2012.12.
 Structure and function of Chinese sturgeon growth hormone receptor and the mechanism through which growth hormone-binding protein is generated. Funded by National Natural Science Foundation of China (Grant No: 30460036), 2005.01-2007.12.
 Dongsong Nie. Hui Li. Yu Liu. Zhiyong Liao. Role of Spata34 in cell proliferation and its expression pattern in postnatal development of rat testis. Molecular Biology Reports, 2018 Oct 19. doi: 10.1007/s11033-018-4439-6. [Epub ahead of print]
 Jiming Li, Jingjing Zeng, Lianpin Wu, Luyuan Tao, Zhiyong Liao, Maoping Chu, Lei Li. Loss of P53 regresses cardiac remodeling induced by pressure overload partially through inhibiting HIF1α signaling in mice. Biochemical and Biophysical Research Communications 2018, 501: 394-399.  Fanfhua Gong, Zhiyong Liao, Qiongzhen Chen. FGF1 improves functional recovery through inducing PRDX1 to reduce autophagy and ROS after spinal cord injury. Journal of Cellular and Molecular Medicine 2018, 22:2727-2738.
 You Xiuling, Liu Liu, Li Xiuyu, Du Hejun, Nie Dongsong, Zhang Xu, Tong Haibing, Wu Mimgjiang, Gao Yitian, Liao Zhiyong. Immune response of interferon-γ-inducible lysosomal thiol reductase (GILT) from Chinese sturgeon (Acipenser sinensis) to microbial invasion and its antioxdative activity in lipopolysaccharides-treated mammalian dentritic cells. Fish Shellfish Immunology 2018, 72: 356-366.
 Tong Haibing, Qi D, Guan X, Jiang G, Liao Zhiyong, Zhang Xu, Chen Peichao, Li Nan, Wu Mingjiang. c-Abl tyrosine kinase regulates neutrophil crawling behavior under fluid shear stress via Rac/PAK/LIMK/cofilin signaling axis. Journal of Cell and Biochemistry 2018, 119: 2806-2817.
 Li Xiuyu, Du Hejun, Liu Liu, You Xiuling, Wu Mingjiang, Liao Zhiyong. MHC class II alpha, beta and MHC class II-associated invariant chains from Chinese sturgeon (Acipenser sinensis) and their response to immune stimulation. Fish Shellfish Immunology 2017, 70:1-12.
 Chen Peichao, He Dan, Zhang Ya, Yang S, Chen L, Wang S, Zou Huixi, Liao Zhiyong, Zhang Xu, Wu Mingjiang. Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependent cytoprotection and ameliorate stress insult during aging. Food and Function 2016, 7:4576-4588.
 Jingjing Chu, Bolun Hu, Zhiyong Liao, Xingguo Zhang. Copper- catalyzed three-component tandem cyclization for one-pot synthesis of 1,4-benzothiazines. The Journal of Organic Chemistry 2016, 81: 8647-8652.
 You Xiuling, Sheng Jianghong, Liu Liu, Nie Dongsong, Liao Zhiyong. Three ferritin subunit analogs in Chinese giant salamander (Andrias davidianus) and their response to microbial stimulation. Molecular Immunology 2015, 67: 642-651.
 Liao Zhiyong, Chen Xiaojun, Nie Dongsong, Wang Jiajia, Wu Mingjiang. A RING finger protein 114 (RNF114) homolog from Chinese sturgeon (Acipenser sinensis) possesses immune-regulation properties via modulating RIG-I signaling pathway-mediated interferon expression. Fish Shellfish Immunology 2014, 41: 507-516.
 Bolun Hu, Chunlin Li, Zhiyong Liao, Xingguo Zhang. Tetrabutylammonium bromide catalyzed tandem addition/cyclization of o-aralkynylaryl aldehydes with trimethyl(trifluoromethyl)silane: synthesis of trifluoromethyl group containing phthalans. SYNLETT 2013, 24: 2748-2750.
 Liao Zhiyong, Wu Zhihua, Wu Mingjiang. Cirsium japonicum flavones enhance adipocyte differentiation and glucose uptake in 3T3-L1 cells. Biological & Pharmaceutical Bulletin 2012, 35: 855-860.
 Sudhanshu Shukla, Ken-ichi Fujita, Qi Xiao, Zhiyong Liao, Susan Gareld, Srinivasa M. Srinivasula. A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface. Apoptosis 2011, 16: 162-173.
 Zhiyong Liao, Mingjiang Wu, Xiaoli Chen. Anti-diabetic effect of flavones from Cirsium japonicum DC in diabetic rats. Archives of Pharmacal Research 2010, 33: 353-362.
 Liao Zhiyong, Chen Xiaoli, Wu Mingjiang. Molecular cloning and functional analysis of Chinese sturgeon (Acipenser sinensis) growth hormone receptor. Science in China C Life Science 2009, 52:911-921.