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博士风采

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金立波

来源:生命与环境科学学院 日期:2022-08-26浏览量:

  个人简介:

金立波,男,博士,副研究员,硕士研究生导师

    温州大学生命科学研究院 常务副院长

    温州市生物医药协同创新中心  主任

主要研究方向:

生物反应器,生物医用材料、药物递送系统研究与开发等。


主要社会兼职:

全国卫生产业企业管理协会烧伤与皮肤再生新质医疗分会   副会长兼秘书长

中国研究型医院创面防治与损伤组织修复专业委员会     委员

浙江创面修复与转化应用中心   副主任

生长因子浙江省工程研究中心   副主任

浙江省生物医药协同创新中心   执行主任

温州市瓯海区生命健康产业协会  常务理事

发表论文(一作及通讯作者)

1)Qu L#, Liu F#, Fang Y#, Wang L, Chen H, Yang Q, Dong H, Jin L*, Wu W*, Sun D*. Improvement in Zebrafish with Diabetes and Alzheimer's Disease Treated with Pasteurized Akkermansia muciniphila. Microbiol Spectr. 2023 Jun 15;11(3) (IF:9.043) (通讯作者)

2Lei Wang, Fan Liu, Yimeng Fang, Jiahui Ma, Jiawei Wang, Linkai Qu, Qinsi Yang, Wei Wu* ,Libo Jin*, Da Sun*. Advances in Zebrafish as a Comprehensive Model of Mental Disorders", Depression and Anxiety, vol. 2023, Article ID 6663141, 48 pages, 2023. https://doi.org/10.1155/2023/6663141.(IF:7.04) (通讯作者)

2Chen H#, Lei P#, Ji H#, Yang Q, Peng B, Ma J, Fang Y, Qu L, Li H, Wu W*, Jin L*, Sun D*. Advances in Escherichia coli Nissle 1917 as a customizable drug delivery system for disease treatment and diagnosis strategies. Mater Today Bio. 2023 Jan 6;18:100543. doi: 10.1016/j.mtbio.2023.100543. PMID: 36647536; PMCID: PMC9840185. (IF:10.761) (通讯作者)

3Liu Y#, Chen Q, # Li Y, Bi L, He Z, Shao C, Jin L*, Peng R*, Zhang X*. Advances in FGFs for diabetes care applications. Life Sci. 2022 Dec 1;310:121015. doi: 10.1016/j.lfs.2022.121015. Epub 2022 Sep 28. PMID: 36179818. (IF:6.78) (通讯作者)

4Jiahui Ma#Ling Yong#Pengyu Lei#Hua LiYimeng FangLei WangHaojie ChenQi ZhouWei WuLibo Jin*, Da Sun*, Xingxing Zhang* .Advances in microRNA from adipose-derived mesenchymal stem cells-derived exosome: focusing on wound healing. Journal of Materials Chemistry B .DOI: 10.1039/D2TB01987F (IF:7.571) (通讯作者)

5Zhang Y#, Huang H#, Jin L*, Lin S *. Anticarcinogenic Effects of Isothiocyanates on Hepatocellular Carcinoma. Int J Mol Sci. 2022 Nov 10;23(22):13834. doi: 10.3390/ijms232213834. PMID: 36430307; PMCID: PMC9693344.IF:2.339(通讯作者)

6Liu F, Qu L, Li H, He J, Wang L, Fang Y, Yan X, Yang Q, Peng B, Wu W, Jin L*, Sun D*. Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases. Pharmaceutics. 2022 Oct 27;14(11):2308. doi: 10.3390/pharmaceutics14112308. PMID: 36365128; PMCID: PMC9697978. (IF:6.525) (通讯作者)

7Liu Y, Chen Q, Li Y, Bi L, Jin L*, Peng R*. Toxic Effects of Cadmium on Fish. Toxics. 2022 Oct 19;10(10):622. doi: 10.3390/toxics10100622. PMID: 36287901; PMCID: PMC9608472. (IF:4.472) (通讯作者)

8Chen Q#, Ji H#, Lin Y, Chen Z, Liu Y, Jin L*, Peng R*. LncRNAs regulate ferroptosis to affect diabetes and its complications. Front Physiol. 2022 Sep 26;13:993904. doi: 10.3389/fphys.2022.993904. PMID: 36225311; PMCID: PMC9548856. (IF:4.755) (通讯作者)

9Ma J, Lei P, Chen H, Wang L, Fang Y, Yan X, Yang Q, Peng B, Jin L, Sun D. Advances in lncRNAs from stem cell-derived exosome for the treatment of cardiovascular diseases. Front Pharmacol. 2022 Sep 6;13:986683. doi: 10.3389/fphar.2022.986683. PMID: 36147326; PMCID: PMC9486024. (IF:5.988) (通讯作者)

10Lei P#, Chen H#, Ma J#, Fang Y, Qu L, Yang Q, Peng B, Zhang X, Jin L*, Sun D*. Research progress on extraction technology and biomedical function of natural sugar substitutes. Front Nutr. 2022 Aug 3;9:952147. doi: 10.3389/fnut.2022.952147. PMID: 36034890; PMCID: PMC9414081. (IF:6.590) (通讯作者)

11Lei WangJiahui MaWei WuYimeng FangFan LiuQinsi YangXiang HuXujiang GuZhiying HeDa Sun*Libo Jin*Xingxing Zhang*.Effect of aerobic exercise as a treatment on type 2 diabetes mellitus with depression-like behavior zebrafish.life sciences. Volume 300,2022,120578,ISSN 0024-3205,https://doi.org/10.1016/j.lfs.2022.120578.  (IF:5.037) (通讯作者)

12Yinai Liu,#Qianqian Chen,# Yaoqi Li, Liuliu Bi, Sue Lin, Hao Ji, Da Sun, Libo Jin*, Renyi Peng*.Hydrogen sulfide-induced oxidative stress mediated apoptosis via mitochondria pathway in embryo-larval stages of zebrafish,Ecotoxicology and Environmental Safety,Volume 239,2022,113666,ISSN 0147-6513, (IF:6.291) (通讯作者)

13Jin L*, Wang Y, Liu X, Peng R, Lin S, Sun D, Ji H, Wang L, Zhang Y, Ahmad N. Codon optimization of chicken β Gallinacin-3 gene results in constitutive expression and enhanced antimicrobial activity in transgenic Medicago sativa L. Gene. 2022 Aug 15;835:146656. doi: 10.1016/j.gene.2022.146656. PMID: 35680025. (IF:3.913) (第一作者)

14Yaoqi Li,#Qianqian Chen,# Yinai Liu, Liuliu Bi,Libo Jin*,Ke Xu*,Renyi Peng*.High glucose‑induced ROS‑accumulation in embryo‑larval stages of zebrafish leads to mitochondria‑mediated apoptosis. Apoptosis,  (2022.5.21). https://doi.org/10.1007/s10495-022-01731-2 (IF:4.677) (通讯作者)

15 Wang L#, Qu L#, Lin S, Yang Q, Zhang X, Jin L*, Dong H*, Sun D*. Biological Functions and Applications of Antimicrobial Peptides. Curr Protein Pept Sci. 2022;23(4):226-247. doi: 10.2174/1389203723666220519155942. PMID: 35598243. (IF:3.118) (通讯作者)

16Li Y#, Liu Y#, Jin L*, Peng R*. Crosstalk between Ca2+ and Other Regulators Assists Plants in Responding to Abiotic Stress. Plants (Basel). 2022 May 19;11(10):1351. doi: 10.3390/plants11101351. PMID: 35631776; PMCID: PMC9148064. (IF:4.658) (并列第一作者)

17Yaoqi Li; Qiong Nan; Yinai Liu; Sue Lin; Hao Ji; Da Sun; Libo Jin*; Renyi Peng*.Nitric Oxide Alleviates Submergence-Induced Maize Seedling Root Tip Cell Death.Journal of Plant Growth Regulation, 2022, 15(4-2022), SCIE (IF:4.64) (通讯作者)

18You JA, Gong Y, Wu Y, Jin L, Chi Q, Sun D. WGCNA, LASSO and SVM Algorithm Revealed RAC1 Correlated M0 Macrophage and the Risk Score to Predict the Survival of Hepatocellular Carcinoma Patients. Front Genet. 2022 Mar 18;12:730920. doi: 10.3389/fgene.2021.730920. PMID: 35493265; PMCID: PMC9044718. (IF:4.772)三区

19Qu L, Wang L, Ji H, Fang Y, Lei P, Zhang X, Jin L*, Sun D*, Dong H*. Toxic Mechanism and Biological Detoxification of Fumonisins. Toxins (Basel). 2022 Mar 1;14(3):182. doi: 10.3390/toxins14030182. PMID: 35324679; PMCID: PMC8954241. (IF:4.501) (通讯作者)

20Zeng G, Ran Y, Huang X, Li Y, Zhang M, Ding H, Ma Y, Ma H, Jin L*, Sun D*. Optimization of Ultrasonic-Assisted Extraction of Chlorogenic Acid from Tobacco Waste. Int J Environ Res Public Health. 2022 Jan 29;19(3):1555. doi: 10.3390/ijerph19031555. PMID: 35162594; PMCID: PMC8835221. (IF:4.614) (通讯作者)

21Wu F, Shao R, Zheng P, Zhang T, Qiu C, Sui H, Li S, Jin L, Pan H, Jin X, Zou P, Cui R, Xie C. Isoalantolactone Enhances the Antitumor Activity of Doxorubicin by Inducing Reactive Oxygen Species and DNA Damage. Front Oncol. 2022 Jan 25;12:813854. doi: 10.3389/fonc.2022.813854. PMID: 35145916; PMCID: PMC8821528. (IF:5.738) (通讯作者)

22Ji H, Xu K, Dong X, Sun D, Jin L. Sequential Production of ᴅ-xylonate and Ethanol from Non-Detoxified Corncob at Low-pH by Pichia kudriavzevii via a Two-Stage Fermentation Strategy. J Fungi (Basel). 2021 Dec 3;7(12):1038. doi: 10.3390/jof7121038. PMID: 34947020; PMCID: PMC8709110. (IF:5.724) (通讯作者)

23Nguyen Quoc Viet Hoang, Kong Jie, Naveed Ahmad, Ma Xintong, Zhang Xinyue, Wu Yuhang , Wang Nan, Yao Na, Liu Xiuming*, Jin Libo*.Genome-wide identification and expression profiling of flavonoid 3'-hydroxylase gene family in Carthamus tinctorius L.中科院III区,Notulae Botanicae Horti Agrobotanici Cluj-Napoca,2021.11.Volume 49,Issue 4.12509(IF:1.444)四区(通讯作者)

24Haojie Chen#,Hao Ji#,Xiangjun Kong,Pengyu Lei,Qinsi Yang,Wei Wu,Libo Jin*, Da Sun*. Bacterial Ghosts-Based Vaccine and Drug Delivery Systems. Pharmaceutics 2021.11.8, 13(11), 1892. (IF:6.525) (通讯作者)

25Sun Fan,# Naveed Ahmad,# Jin Libo,# Zhang xinyue, Ma Xintong, Nguyen Q. V. HOANG, Ali I. MALLANO, Wang Nan, Yang Zhuoda, Liu Xiuming, Yao Na.Genome-wide investigation of Hydroxycinnamoyl CoA: Shikimate Hydroxycinnamoyl Transferase (HCT) gene family in Carthamus tinctorius L中科院III区,Notulae Botanicae Horti Agrobotanici Cluj-Napoca,2021.09.27.Volume 49,Issue 3.12489(IF:1.444) (并列第一作者)

26Yaoqi Li,#Da Sun,#Ke Xu*,Libo Jin*,Renyi Peng*. Hydrogen Sulfide Enhances Plant Tolerance to Waterlogging Stress. Plants (Basel). 2021 Sep 16;10(9):1928. doi: 10.3390/plants10091928. PMID: 34579462; PMCID: PMC8468677.(IF:3.935) (通讯作者)

27Libo Jin,# Guoming Zeng,# Haojie Chen,Lei Wang,Hao Ji,Sue Lin,Renyi Peng,Da Sun*.Mechanism of lignin degradation via white rot fungi explored using spectral analysis and gas chromatography-mass spectrometry.BioResources. 2021.06.15;Vol16, Issue,5494—5507;(IF:1.614) (第一作者)

28Huang X, Zhu X, Yu Y, Zhu W, Jin L, Zhang X, Li S, Zou P, Xie C, Cui R. Dissecting miRNA signature in colorectal cancer progression and metastasis. Cancer Lett. 2021 Mar 31;501:66-82. doi: 10.1016/j.canlet.2020.12.025. Epub 2020 Dec 29. PMID: 33385486. (IF:9.756)

29Ji H, Xu K, Dong X, Sun D, Peng R, Lin S, Zhang K, Jin L. Transcriptional profiling reveals molecular basis and the role of arginine in response to low-pH stress in Pichia kudriavzevii. J Biosci Bioeng. 2020 Dec;130(6):588-595. doi: 10.1016/j.jbiosc.2020.07.014. Epub 2020 Aug 11. PMID: 32798135. (IF:2.24) (通讯作者)

30Da Sun,Jia Chen,Yuan Wang,Hao Ji,Renyi Peng,Libo Jin*,Wei Wu*.Advances in refunctionalization oferythrocyte-based nanomedicine for enhancing cancer-targeteddrug delivery. Theranostics,2019.09.21;Vol. 9, Issue 23(IF:11.556) (通讯作者)

31Sue Lin,Yingjing Miao,Shiwen Su,Jian Xu,Libo Jin,Da Sun,Renyi Peng,Li Huang,Jiashu Cao. Comprehensive analysis of Ogura cytoplasmic male sterility-related genes in turnip (Brassicarapa ssp. rapifera) using RNA sequencing analysis and bioinformatics.Plos One,2019.06.14,14(6), (IF2.806)

32Jing Zhang,Wenhe Zhu,Benkai Xin,Sue Lin,Libo Jin*and Huiyan Wang*. Development of an antibacterial surface with self-defensive and pH-responsive function.royal society of chemistry biomaterials-science, 2019.06.12;(9)(IF:5.4676),二区(通讯作者)

33Libo Jin,Jin Wu,Saverio Bellusci*,Jin-San Zhang*;Fibroblast Growth Factor 10 and Vertebrate Limb Development;Frontiers in Genetics; 2019.01.079,(705),IF:4.15(第一作者)

34Libo Jin; Jia Chen; Xiaoqing Yan; Chi Zhang; Haishan Tian; Hao Ji; Lin Sue; Renyi Peng; Da Sun.Tripterygium wilfordii polyglycosides inhibit TGF-beta 1/NF-Kappa B signaling pathway and improve renal fibrosis in diabetic nephropathy Acta Medica Mediterranea,2019.02.20;(35), IF:0.835(第一作者)

35Da Sun,Jia Chen,Wei Wu,Ju Tang,Li Luo,Kun Zhang ,Libo Jin, Sue Lin,Yitian Gao,Xiaoqing Yan,Chi Zhang. MiR-802 causes nephropathy by suppressing NF-κB-repressing factor in obese mice and human.Journal of Cellular and Molecular Medicine. 2019.02.07,23(4),(IF:4.658)

36Libo Jin,Yunpeng Wang,Nuo Xu,Dezhong Wang,Xiuming Liu,Renyi Peng,Chao Jiang,Xiaokun Li*;Expression and activity analysis of β Gallinacin-3 in Arabidopsis.Protein expression and purication,2018.04,(144),IF:1.42四区

37FengZhai1, Nuo Xu1, Jing Yang, Yunpeng Wang, Libo Jin, Haiyan Li, Xiaokun Li* and Chao Jiang*. Expression of Human FGF18 by Fusion with Oleosin in Arabidopsis thaliana Seeds. Journal of Plant Biology, (2018). 61(3), doi:10.1007/s12374-015-0527-5 IF:3.15

科研项目

  1.温州市,利用食用型白腐真菌进行水体控藻的研究;20万,第2

  2.温州市,番鸭细小病毒非结构蛋白NS2诱导鸭胚成纤维细胞凋亡的分子机制研究,6万,主持

  3.浙江省,转录因子组合诱导人在纤维细胞重编程为leydig-like细胞及其应用研究,10万第2

  4.温州市,生物质耦合白腐菌强化治理蓝藻水华代谢损伤机制及生物毒理性研究,3万,第2

  5.温州市,一氧化氮(NO)提升水涝灾害后玉米幼苗成活率的研究,3万,第2

  6.温州市,科协博士创新工作站(温州鸥肽医学检验实验室有限公司),主持


授权专利:

1.发明专利:

(1) 一种肥胖性II型糖尿病斑马鱼模型的构建方法及应用;202110667786.2(已授权)

(2) 一种构建糖尿病型斑马鱼模型的方法;202110297218.8(已授权)

(3) 一种适用于糖尿病足使用抗菌面料的制备方法;202110321075X(已授权)

(4) 抗菌载药纱布的制备方法及糖尿病足患者用足套;202010640897X(已授权)

(5) 一种人源角质细胞生长因子2的基因序列、表达载体及生产方法;201711441853.92(已授权)

(6) 基于药用植物来源的粉末和药机,2019100396638.9(已授权)

(7) 手术刀清洗装置;201910014373.7;(已授权)

(8) 小型药用植物材料粉碎机,201910065785.3 (已授权)

(9) 一种弧度高度可调的扁平足矫正鞋垫,申请号:2020107698452(已授权)

(10) 一种糖尿病足专用高透气纱布的制备方法, 2020106415437

(11) 抑制库德毕赤酵母菌株细胞聚集的方法、构建和应用, 2020105222282(已授权)

2.实用新型:

(12) 一种新型医学检验管 201821243667.X(已授权)

(13) 一种便携式医学检验箱 201821243526.8 (已授权)

(14) 一种中药材烘干装置;201822083503.6;(已授权)

(15) 蛋白药物临实验医用箱;201920110142.1;(已授权)

(16) 医用棉签卷棉机;201920053482.5;(已授权)

(17) 康复行走训练医用拐杖;201822169717.5;(已授权)

(18) 一种斑马鱼有氧运动实验装置;2021228817540(已授权)

(19) 一种具有交换磁场功能的保健鞋;2021213879050(已授权)

(20) 一种斑马鱼养殖用过滤装置;202121396000X(已授权)

(21) 一种斑马鱼养殖用多功能观察系统;202121396032X(已授权)

(22) 一种用于斑马鱼养殖观察的养殖的净化装置;2021213974375(已授权)

(23) 一种斑马鱼养殖用供水装置;2021213957350(已授权)

(24) 一种斑马鱼养殖用定时投食装置;2021213957740(已授权)

(25) 一种空气过滤结构层、空气净化器、口罩;2020202792330(已授权)


平台项目

1.浙江省级平台项目:浙江省生物医药协同创新中心,配套500万(实际负责人)

2.浙江省级平台项目:生长因子药物开发浙江省工程实验室,300万(实际负责人)

3.温州市级平台项目:温州市生物医药协同创新中心,150万。(主持工作)

4.省部共建:教育部省部共建生物医药协同创新中心。(第二单位参与)

指导竞赛获奖

1.浙江省第八届国际互联网+创新创业大赛,银奖

2.浙江省第十三届挑战杯大学生创新创业大赛,银奖

3.2022暑期社会实践活动优秀团队,优秀指导教师,十佳精品,大挑立项。

4.浙江省第十八届“挑战杯”大学生课外学术科技作品竞赛,金奖。

5.2023年第十八届“挑战杯”全国大学生课外科技作品竞赛获三等奖等。


联系电话:13091930181

电子邮箱:20160121@wzu.edu.cn