个人简介

林苏娥，女，博士，瓯江特聘教授/副研究员，硕士生导师

主要研究方向

植物有性生殖发育及其分子调控机制、植物对环境胁迫的响应机制、天然产物资源活性成分开发与利用。

发表论文

[1] Dandan Liu, Yuanrong He, Yijie Wang, Weiwei Chen, Jianli Yang, Yuzhi Zhang, Yaoyao Feng, Yuxue Zhao, Sue Lin*, Li Huang*. Tetrad stage transient cold stress skews auxin-mediated energy metabolism balance in Chinese cabbage pollen. Plant Physiology, 2024, 195: 1312-1332.

[2] Dexi Shi, Huiting Huang, Yuting Zhang, Zhihao Qian, Jiao Du, Li Huang, Xiufeng Yan*, Sue Lin*. The roles of non-coding RNAs in male reproductive development and abiotic stress responses during this unique process in flowering plants. Plant Science, 2024, 341: 111995.

[3] Zhihao Qian, Dexi Shi, Hongxia Zhang, Zhenzhen Li, Li Huang, Xiufeng Yan*, Sue Lin*. Transcription factors and their regulatory roles in the male gametophyte development of flowering plants. International Journal of Molecular Sciences, 2024, 25(1): 566.

[4] Jiao Du, Yuting Zhang, Jiajia Chen, Libo Jin, Liying Pan, Pengyu Lei, Sue Lin*. Phenethyl isothiocyanate inhibits the carcinogenic properties of hepatocellular carcinoma Huh7.5.1 cells by activating MAPK/PI3K-Akt/p53 signaling pathways. PeerJ, 2024, 12: e17532.

[5] Yuting Zhang, Jiao Du, Libo Jin, Liying Pan, Xiufeng Yan*, Sue Lin*. Iberverin exhibits antineoplastic activities against human hepatocellular carcinoma via DNA damage-mediated cell cycle arrest and mitochondrial-related apoptosis. Frontiers in Pharmacology, 2023, 14: 1326346.

[6] Yuting Zhang, Huiting Huang, Libo Jin*, Sue Lin*. Anticarcinogenic effects of isothiocyanates on hepatocellular carcinoma. International Journal of Molecular Sciences, 2022, 23(22): 13834.

[7] Sue Lin*, Yingjing Miao, Huiting Huang, Yuting Zhang, Li Huang and Jiashu Cao. Arabinogalactan proteins: focus on the role in cellulose synthesis and deposition during plant cell wall biogenesis. International Journal of Molecular Sciences, 2022, 23: 6578.

[8] Huiting Huang, Yingjing Miao, Yuting Zhang, Li Huang, Jiashu Cao*, Sue Lin*. Comprehensive analysis of arabinogalactan protein-encoding genes reveals the involvement of three BrFLA genes in pollen germination in Brassica rapa. International Journal of Molecular Sciences, 2021, 22: 13142.

[9] Yingjing Miao, Jiashu Cao, Li Huang, Youjian Yu, Sue Lin*. FLA14 is required for pollen development and preventing premature pollen germination under high humidity in Arabidopsis. BMC Plant Biology, 2021, 21: 254.

[10] Sue Lin*, Shiwen Su, Libo Jin, Renyi Peng, Da Sun, Hao Ji, Youjian Yu, Jian Xu*. Identification of microRNAs and their targets in inflorescences of an Ogura-type cytoplasmic male-sterile line and its maintainer fertile line of turnip (Brassica rapa ssp. rapifera) via high-throughput sequencing analysis. PLoS ONE, 2020, 15(7): e0236829.

[11] Sue Lin*, Yingjing Miao, Shiwen Su, Jian Xu, Libo Jin, Da Sun, Renyi Peng, Li Huang, Jiashu Cao. Comprehensive analysis of Ogura cytoplasmic male sterility-related genes in turnip (Brassica rapa ssp. rapifera) using RNA sequencing analysis and bioinformatics. PLoS ONE, 2019, 14(6): e0218029.

[12] Sue Lin, Li Huang, Yingjing Miao, Youjian Yu, Renyi Peng, Jiashu Cao*. Constitutive overexpression of the classical arabinogalactan protein gene BcMF18 in Arabidopsis causes defects in pollen intine morphogenesis. Plant Growth Regulation, 2019, 88: 159-171.

[13] Sue Lin, Xiaoyan Yue, Yingjing Miao, Youjian Yu, Heng Dong, Li Huang*, Jiashu Cao*. The distinct functions of two classical arabinogalactan proteins BcMF8 and BcMF18 during pollen wall development in Brassica campestris. Plant Journal, 2018, 94: 60-76.

[14] Sue Lin, Li Huang, Xiaolin Yu, Xingpeng Xiong, Xiaoyan Yue, Tingting Liu, Ying Liang, Meiling Lv, Jiashu Cao*. Characterization and expression pattern of BcMF23a and BcMF23b, two putative pectin methylesterase genes involved in pollen development in Brassica campestris ssp. chinensis. Molecular Biology Reports, 2017, 44: 139-148.

[15] Sue Lin, Heng Dong, Fang Zhang, Lin Qiu, Fangzhan Wang, Jiashu Cao, Li Huang*. BcMF8, a putative pollen-specific arabinogalactan protein gene, contributes to pollen wall development, aperture formation and pollen tube growth in Brassica campestris. Annals of Botany, 2014, 113: 777-788.

[16] 饶立兵, 胡齐赞, 余小林, 王芳展, 林苏娥*. 大白菜抽薹性状相关SSR分子标记的筛选. 分子植物育种, 2015, 13(8): 1876-1793.

[17] 林苏娥, 黄鹂*, 曹家树. 阿拉伯半乳糖蛋白在被子植物中的功能. 中国细胞生物学学报, 2011, 33(3): 306-312.

[18] Yijie Wang, Huiyan Zhou, Yuanrong He, Xiuping Shen, Sue Lin, Li Huang*. MYB transcription factors and their roles in the male reproductive development of flowering plants. Plant Science, 2023, 335: 111811.

[19] Dong Zhou, Caizhi Chen, Zongmin Jin, Jingwen Chen, Sue Lin, Tao Lyu, Dandan Liu, Xinpeng Xiong, Jiashu Cao, Li Huang*. Transcript profiling analysis and ncRNAs’ identification of male-sterile systems of Brassica campestris reveal new insights into the mechanism underlying anther and pollen development. Frontiers in Plant Science, 2022, 13: 806865.

[20] Haiyan Lin, Jiayi Sun, Zhiwei Hu, Chenxi Cheng, Sue Lin, Huixi Zou and Xiufeng Yan. Variation in glucosinolate accumulation among different sprout and seedling stages of broccoli (Brassica oleracea var. italica). Plants, 2022, 11: 1563.

[21] Hao Ji*, Ke Xu, Xiameng Dong, Da Sun, Renyi Peng, Sue Lin, Kailun Zhang, Libo Jin. Transcriptional profiling reveals molecular basis and the role of arginine in response to low-pH stress in Pichia kudriavzevii. Journal of Bioscience and Bioengineering, 2020, 130(6): 588-595.

[22] Huiyan Zhou, Yanhong Liu, Yuwei Liang, Dong Zhou, Shuifeng Li, Sue Lin, Heng Dong, Li Huang*. The function of histone lysine methylation related SET domain group proteins in plants. Protein Science, 2020, 29(5): 1120-1137.

[23] Renyi Peng, Hao Ji, Libo Jin, Sue Lin, Yijiang Huang, Ke Xu, Qinsi Yang, Da Sun*, Wei Wu*. Macrophage-based therapies for atherosclerosis management. Journal of Immunology Research, 2020, 23(6093): 1-11.

[24] Yuwei Liang, Yuzhi Zhang, Liai Xu, Dong Zhou, Zongmin Jin, Huiyan Zhou, Sue Lin, Jiashu Cao, Li Huang*. CircRNA expression pattern and ceRNA and miRNA-mRNA networks involved in anther development in the CMS line of Brassica campestris. International Journal of Molecular Sciences, 2019, 20: 4808.

[25] Da Sun*, Jia Chen, Haiqi Hu, Sue Lin, Libo Jin, Li Luo, Xiaoqing Yan, Chi Zhang. Acanthopanax senticosus polysaccharide suppressing proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells is associated with Wnt/β-catenin signaling. Neoplasma, 2019, 66(4): 555-563.

[26] Da Sun*, Jia Chen, Wei Wu, Ju Tang, Li Luo, Kun Zhang, Libo Jin, Sue Lin, Yitian Gao, Xiaoqing Yan, Chi Zhang. MiR-802 causes nephropathy by suppressing NF-κB-repressing factor in obese mice and human. Journal of Cellular and Molecular Medicine, 2019, 23(4): 2863-2871.

[27] Libo Jin, Jia Chen, Xiaoqing Yan, Chi Zhang, Haishan Tian, Hao Ji, Sue Lin, Renyi Peng, Da Sun*. Tripterygium wilfordii polyglycosides inhibit TGF-beta 1/NF-Kappa B signaling pathway and improve renal fibrosis in diabetic nephropathy. Acta Medica Mediterranea, 2019, 35: 2787.

[28] Jing Zhang, Wenhe Zhu, Benkai Xin, Sue Lin, Libo Jin*, Huiyan Wang*. Development of an antibacterial surface with a self-defensive and pH-responsive function. Biomaterials Science, 2019, 7: 3795.

[29] Xiuping Shen, Liai Xu, Yanhong Liu, Heng Dong, Dong Zhou, Yuzhi Zhang, Sue Lin, Jiashu Cao, Li Huang*. Comparative transcriptome analysis and ChIP-sequencing reveals stage-specific gene expression and regulation profiles associated with pollen wall formation in Brassica rapa. BMC Genomics, 2019, 20: 264.

[30] Xiaoyan Yue, Sue Lin, Youjian Yu, Li Huang, Jiashu Cao*. The putative pectin methylesterase gene, BcMF23a, is required for microspore development and pollen tube growth in Brassica campestris. Plant Cell Reports, 2018, 37: 1003-1009.

[31] Li Huang*, Heng Dong, Dong Zhou, Ming Li, Yanhong Liu, Fang Zhang, Yaoyao Feng, Dongliang Yu, Sue Lin, Jiashu Cao. Systematic identification of long non-coding RNAs during pollen development and fertilization in Brassica rapa. Plant Journal, 2018, 96: 203-222.

[32] Tianyu Han, Heng Dong, Jie Cui, Ming Li, Sue Lin, Jiashu Cao, Li Huang*. Genome-wide identification, molecular evolution analysis, and expression profiling of the genes encoding putative classical arabinogalactan proteins (AGPs), lysine-rich AGPs, and AG peptides in Brassica rapa. Frontiers in Plant Science, 2017, 8: 397.

[33] Heng Dong, Dandan Liu, Tianyu Han, Yuxue Zhao, Ji Sun, Sue Lin, Jiashu Cao, Zhong-Hua Chen, Li Huang*. Diversification and evolution of the SDG gene family in Brassica rapa after the whole genome triolication. Scientific reports, 2015, 5: 16851.

[34] 冯瑶瑶, 孙继, 俞洋, 武婷, 刘丹丹, 林苏娥, 赵玉雪, 黄鹂*. 温度胁迫对植物花粉发育的影响. 中国细胞生物学学报, 2019, 41(1): 141-149.

科研课题

[1] 国家自然科学基金面上项目，31972418，白菜花粉响应低温胁迫的lncRNA-BrCBF4-COR基因调控通路研究，2020/01-2023/12，58万元，主持

[2] 国家自然科学基金青年科学基金项目，31501764，白菜花粉特异表达的两个类成束阿拉伯半乳糖蛋白基因的功能和相互关系分析，2016/01-2018/12，18万元，主持

[3] 浙江省自然科学基金探索项目，LY21C150004，长链非编码RNA lncBrCPL3在白菜花粉低温应答中的功能研究，2021/01-2023/12，10万元，主持

[4] 温州市基础性公益科研项目，N20210003，十字花科蔬菜中芥子油苷水解产物异硫氰酸酯对肝癌细胞致癌活性的影响及作用机制研究，2022/01-2023/12，4万元，主持

[5] 科技部，国家重点研发计划“政府间国际科技创新合作”重点专项，2022YFE0108300，西兰花芥子油苷代谢调控机制的解析与利用，2022/09-2025/08，300万元，参与

[6] 温州市种子种苗科技创新专项项目，Z20160008，盘菜细胞质雄性不育系‘BY10-2A’及其保持系差异表达的miRNAs及其靶基因鉴定，2016/09-2019/12，10万元，主持

[7] 温州市科技计划项目，KZ1712007，利用食用型白腐真菌进行水体控藻的研究，2017/11-2020/06，20万元，参加，排名第4

[8] 温州市科技计划项目，N20170005，一氧化氮（NO）提升水涝灾害后玉米幼苗成活率的研究，2017/10-2018/12，3万元，参加，排名第5

[9] 浙江省种子管理总站项目，2014005，温州市地方特色蔬菜种质资源收集保护，2014/11-2017/12，50万元，参加，排名第4

[10] 国家自然科学基金面上项目，31372078，白菜花粉特异lncRNA对花粉发育过程基因表达的调控及其机制研究，2014/01-2017/12，78万元，参加，排名第4

[11] 国家自然科学基金面上项目，31272176，白菜花粉发育相关PG基因的进化、表达和功能分化研究，2013/01-2016/12，85万元，参加，排名第6

[12] 国家重点基础研究发展计划（973计划）项目（课题），2012CB113901，主要蔬菜重要品质性状形成的遗传机理与分子改良（课题：蔬菜品质性状全基因组关联分析），2012/04-2014/12，110万元，参加，排名第2

专著、获奖情况及个人荣誉

[1] 2022年入选第二批“浙江省高校领军人才培养计划”青年优秀人才

[2] 2020年入选温州市“高层次人才特殊支持计划”科技创新青年拔尖人才

[3] 2016年入选温州市“551人才工程”第二层次培养

承担的主要课程

生命科学与生技技术导论

联系电话：13566198601（678601）；18067780005

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